Description:
The 6410 Triple Quadrupole LC/MS achieves sensitivity and resolution specifications after autotune without manual user intervention.
| Parameter | Measure | Specification |
| MS/MS sensitivity and repeatability | 0.5 pg of reserpine injected on column, ESI source, three concurrent MRM acquisitions, quantifying on the transition m/z 609 to 195. |
Signal-to-noise ratio >20:1, where noise = 5x RMS |
| Mass resolution | Three settings (FWHM) Unit: 0.7 u; Wide: 1.2 u; Widest: 2.5 u |
|
| Mass accuracy | 0.1 u across the mass range | |
| Mass stability | <0.1 u in 24 h | |
| Dynamic range | >6.5 × 10 6 |
|
| Mass range | m/z 15–1,650 |
|
| Scan rate | 5,200 u/sec | |
| Scan modes | MS scan, MS/MS product ion scan, MRM, MS/MS neutral loss/gain scan and precursor ion scan, SIM |
|
| Minimum MRM dwell time | 5 ms with 10 MRMs | |
| MRM transitions | 99 per time segment, thousands possible with multiple segments |
|
| Positive/negative polarity switching | Time segment dependent | Inter-segment delay of 1.5 sec |
| Collision cell | High-pressure, hexapole with linear acceleration |
|
| Cross-talk | None detectable |
General System Specifications
| Parameter | Measure |
| Single point of control | Single-point data system method capability with full control of Agilent 1100 and 1200 Series HPLC systems and 6410 Triple Quadrupole LC/MS |
| Time programming | • Positive/negative polarity switching in a time segment • Scan and SIM or MRM (plus other modes of data collection) • Solvent divert through calibrant delivery system valve • Possible 99-time segments with potential 99 MRMs per-time window |
| Wide range of ionization sources | • Electrospray (ESI) • Nanospray with HPLC-Chip Cube MS interface • Atmospheric pressure chemical ionization (APCI) • Multimode source (simultaneous ESI and APCI) |
| Autotune | Automated optimization of ion optics and mass axis calibration |
| Solvent declustering | Countercurrent gas |
| Detector | High-energy conversion dynode and removable electron multiplier horn |
| Vacuum system | One triple-stage turbomolecular pump with one mechanical pump |
| Warranty | First year expanded warranty to include all labor, parts, and travel expenses. Includes preventive maintenance and certain consumables. |
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